Volume 42 No 5  Cover Story

Fluorescent photomicrographs showing apotosis induced by combined treatment of As2O3 and berberine. Human neuroblastoma SH-SY5Y cells are treated with 2μM As2O3 and 75μg/ml berberine and stained with 4’, 6-diamidine-2-phenylindole (DAPI). Combined treatment of As2O3 and berberine induces the chromatin condensation and nuclear fragment of SH-SY5Y cells.