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Journal of Korean Neurosurgical Society 2006;39(3): 210-214.
Microbleeds in Patients with Primary Intracerebral Hemorrhages.
Il Man Kim, Man Bin Yim, Eun Ik Son, Sung Il Sohn, Chul Ho Sohn
1Department of Neurosurgery, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea. bach1158@dsmc.or.kr
2Department of Neurology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.
3Department of Diagnostic Radiology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.
ABSTRACT
OBJECTIVE
We investigate risk factors of cerebral microbleeds(MBs) and their relation to concomitant magnetic resonance (MR) findings in intracerebral hemorrhages(ICHs) patients.
METHODS
We studied 100 consecutive patients with primary ICH over a 1-year period. These patients underwent brain MR images using 3.0-T scanners within the first week of the hemorrhage. MBs and old hematomas were located and counted by using T2*-weighted gradient-echo MR imaging. We also counted lacunes and graded white matter and periventricular hyperintensity on T1- and T2-weighted spin-echo sequences. The association between MBs and vascular risk factors and MR abnormalities were analyzed.
RESULTS
MBs were seen in 77 of ICH patients, and their number ranged from 1 to 65 lesions (mean 11, median 6). The locations of MBs were subcortex-cortex (40.6%), basal ganglia (26.7%), thalamus (14.1%), brain stem (12.5%), and cerebellum (9.1%). Analysis of clinical data revealed that age, hypertension, history of stroke, and duration of hypertension were frequently associated with MBs. The incidence of lacunes, old hematomas, and advanced leukoaraiosis was significantly higher in the MBs group, compared with the patients without MBs.
CONCLUSION
MBs are frequently observed in ICH patients with advancing age, chronic hypertension, and previous hemorrhagic stroke, and are also closely related with morphological signs of occlusive type microangiopathy, such as lacunar infarct and severe leukoaraiosis.
Key Words: Intracerebral hemorrhage; Magnetic resonance image; Microbleed; Hypertension; Microangiopathy
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