Effect of Intraarterially Administered Abciximab(Glycoprotein IIb-IIIa Inhibitor) in the Acute Cerebral Vascular Occlusion.

Kim, Yong Man; Choe, Woo Jin; Kwon, O Ki; Lee, Chae Heuck; Park, Hyo Il; Koh, Young Cho

Original Article

Journal of Korean Neurosurgical Society 2004;35(2): 147-152.

Yong Man Kim, Woo Jin Choe, O Ki Kwon, Chae Heuck Lee, Hyo Il Park, Young Cho Koh

Department of Neurosurgery, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.

ABSTRACT

OBJECTIVE
The authors report the safe recanalization after intraarterial injection of abciximab(glycoprotein IIb-IIIa inhibitor) in the acute cerebral vascular occlusion from the thromboembolism. METHODS: Eight patients with acute occlusion of cerebral arteries were treated by using an intraarterial infusion of urokinase and abciximab(Reopro(R)). Six patients had acute thromboembolic complication of endovascular therapy and two patients had acute basilar artery occlusion. Authors used mean 428, 000 units of the urokinase, and mean 6.2mg of the abciximab. In six cases, intraarterial urokinase and abciximab were infused shortly after the event of thrombosis duration endovascular procedure. RESULTS: In all cases, successful recanalization of thrombotic artery was achieved by using intraarterial abciximab and urokinase without bleeding complication. Seven patients recovered without neurologic deficit and one patient remained in locked-in neurological state. CONCLUSION: The authors believe that the intraarterial infusion of abxicimab even in small dose is effective and safe recanalization method in acute thrombotic occlusion of cerebral arteries, but further evaluation and study are needed.

Key Words: Abciximab; Intraarterial recanalization; Acute cerebral vascular occlusion