Brain Protective Effects of Mild Hypothermia on the Reversible Cerebral Ischemia in the Rat.

Song, Kwang Chul; Bae, Jun Ho; Choi, Byung Yon; Kim, Seong Ho; Bae, Jang Ho; Kim, Oh Lyong; Cho, Soo Ho; Shin, Hyoun Jin

Original Article

Journal of Korean Neurosurgical Society 2002;31(6): 585-592.

Kwang Chul Song, Jun Ho Bae, Byung Yon Choi, Seong Ho Kim, Jang Ho Bae, Oh Lyong Kim, Soo Ho Cho, Hyoun Jin Shin

¹Department of Neurosurgery, Yeungnam University, College of Medicine, Daegu, Korea.
²Department of Research Institute of Medical Engineering, Yeungnam University, College of Medicine, Daegu, Korea.
³Department of Neurosurgery, Bo-Kwang Hospital, Daegu, Korea.

ABSTRACT

OBJECTIVE
The authors report a experimental research of brain protective effects of mild hypothermia on the reversible cerebral ischemia in the rat.
METHODS
We divided the experimental objects into two groups;the control group of normal temperature(36.5degreesC) and the experimental group of hypothermia, and also the latter into three group;group I (33.5degreesC), group II(30.5degreesC), group III(27.5degreesC) depending on the body temperature of hypothermia. The hypothermia was maintained for two hours of middle cerebral artery occlusion and initial 30 minutes of reperfusion and again the temperature was elevated and maintained to 36.5degreesC. Then the cerebral infarct volume was measured at 12 hours after reperfusion of middle cerebral artery.
RESULTS
The physiological parameters between the control and the each experimental group were insignificant except the depression of mean systemic arterial pressure in group II and III during hypothermia (p<0.05). As the temperature depression became deeper, the cerebral infarct volume was reduced; 0.99+/-0.26% in group I, 0.66+/-0.14% in group II, and 0.17+/-0.05% in group III. In each experimental group, compared with 2.13+/-0.53% in the control group the cerebral infarct volume was reduced so much that the result was significant statistically. In addition to that, the comparison of cerebral infarct volume between group I and III was proved to be significant statistically(p<0.05), but meaningless between group I and group II.
CONCLUSION
It is suggested that mild hypothermia of 33.5degreesC for a short time(2.5hours) has the brain protective effect on reversible focal cerebral ischemia and reperfusion injury without the change of physiologic parameters.

Key Words: Reversible cerebral ischemia; Mild hypothermia