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Journal of Korean Neurosurgical Society 2002;31(1): 60-64. |
| Familial Occurrence of Cerebellar Gliomas. |
| Young Won Hwang, Moo Seong Kim, Hong Bo Sim, Sun Il Lee, Yong Tae Jung, Soo Chun Kim, Jae Hong Sim |
| Department of Neurosurgery, Inje University, Pusan Paik Hospital, Pusan, Korea. |
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| ABSTRACT |
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Several cases of familial occurrence of gliomas have been reported, but little has been known on the importance of genetic factors, which indeed remains controversial. In establishing the genetic basis for cancer susceptibility, the evaluation of a single family is perhaps the most satisfactory and meaningful approach. We report a family in which the 47-year-old father had glioblastoma in cerebellar vermis and his 14-year-old daughter developed pilocytic astrocytoma in cerebellar hemisphere. Karyotypic analysis of this family showed no abnormal findings in chromosomes. |
| Key Words:
Familial occurrence; Glioma; Genetic factor; Karyotype |
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