Efficacy of Unilateral Pallidotomy for Parkinson's Diesease.

Cho, Woo Jin; Lee, Kyung Jin; Ji, Cheul; Park, Sung Chan; Park, Hea Kwan; Jo, Jung Ki; Cho, Kyung Keun; Rha, Hyung Kyun; Kang, Joon Ki; Choi, Chang Rak

Original Article

Journal of Korean Neurosurgical Society 2001;30(8): 976-980.

Woo Jin Cho, Kyung Jin Lee, Cheul Ji, Sung Chan Park, Hea Kwan Park, Jung Ki Jo, Kyung Keun Cho, Hyung Kyun Rha, Joon Ki Kang, Chang Rak Choi

¹Catholic Neuroscience Center, College of Medicine, The Catholic University, Seoul, Korea.
²Department of Neurosurgery, College of Medicine, The Catholic University, Seoul, Korea.

ABSTRACT

OBJECTIVE
S: For Parkinsonian patients who had not reacted favorably on drug therapy are good candidate for ventroposterolateral pallidotomy, although not curative. We studied these patients after unilateral pallidotomy, to confirm the effectiveness and safety of this procedure.
METHODS
We evaluated the 17 patients with idiopathic Parkinson's diesease who had undergone unilateral posteroventral pallidotomy. All patients responded to levodopa initially. Mean age was 55 years(38-75years), and mean duration of disease was 9.8 years(3-20years). Pre-and postoperative evaluation at 3 month intervals included Unified Parkinson's Disease Rating scale(UPDRS) scoring, Hoehn and Yahr(H and Y) staging, and neuropsychological examinations.
RESULTS
Pallidotomy significantly improved parkinsonian symptom(tremor, rigidity, bradykinesia, dyskinesia, sensory symptom). Nine of 10 patients who showed dyskinesia preoperatively significant improvement. The mean dose of levodopa in 9 patients was lowered. The mean H and Y score and UPDRS score were improved in on and/or off time in 15 patients. Among patients who were not improved, one patient worsened, and the others showed no change. The mean overall UPDRS off score changed from 76 preoperatively to 44(33%) at 6 months and from 70 to 52(25%) at 1 year. Transient surgical morbidity was showen in four patients and included dysarthria, hypotonia and confusion.
CONCLUSION
We conclude that pallidotomy is safe and effective in patients who have levodopa-reponsive parkinsonism with severe symptom fluctuation. Unilateral pallidotomy also considered helpful to ipsilateral symptom. Unilateral pallidotomy can improve all of parkinsonian's symptom and allow to reduce the levodopa medication. Most of patients show satisfactory results.