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Journal of Korean Neurosurgical Society 1996;25(9): 1768-1771.
Is the Phenomenon of Blood-Brain Barrier Disruption Induced with Mannitol All-or-None?.
Soo Han Yoon, Ki Hong Cho, Kyung Gi Cho, Young Min Ahn, Young Hwan Ahn
Department of Neurosurgery, Ajou University School of Medicine, Suwon, Korea.
ABSTRACT
We evaluated the effect of mannitol-induced blood-brain-barrier disruption(BBBD) in 20 rats of the routine-dose mannitol group(1.75g/kg), 7 rats of the small-dose mannitol group(0.87g/kg), and 10 rats of the saline control group. Radioactivity ratios of brain section to plama in the routine dose mannitol group revealed a wide variation of 0.0134 to 0.1747 which was compared to the small dose mannitol group of 0.0107-0.0275 in the plasma albumin space and to the saline control group of 0.0051-0.0174. This result suggest that mannitol-induced BBBD may not be threshold event of all-or-none phenopomenon, but progressive graded reaction with various sensitivity.
Key Words: Blood brain barrier disruption; Mannitol
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