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Journal of Korean Neurosurgical Society 1996;25(7): 1352-1363. |
| Serotonin 1A Receptor Agonist(8 OH DPAT) Reduces Tissue Lesion Volume in the Rat Middle Cerebral Artery Occlusion Model of Ischemia. |
| Do Heum Yoon, Young Soo Kim, Wise Young |
1Department of Neurosurgery, College of Medicine, Yonsei University, Seoul, Korea.
2Department of Neurosurgery, NYU Medical Center, 550 First Avenus, New York, NY 10016, USA. |
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| ABSTRACT |
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We studied the effectiveness of serotonin 1a agonist(8 OH DPAT) on the 24 hour ionic lesion volume produced by permanent occlusion of the middle cerebral artery(MCAo) in rats. A 4-hour intravenous infusion of 30 micro mg/kg/hr of 8 OH DPAT were given starting at 10 minutes after occlusion.
Tissue concentrations of Na, K, and water at infarct and peri-infarct zone were measured by atomic absorption spectroscopy and by wet-dry weight measurements 24 hours after occlusion. Compared with vehicle treatment, 8 OH DPAT treatment reduced tissue water accumulation by 10% and 55% in the frontopyriform cortex(L1) and frontoparietal cortex(L2), sodium accumulation by 20% at L1 and 47% at L2, potassium loss by 24% at L1 and 44% at L2, cell volume fraction loss by 24% at L1 and 47% at L2. Finally the treatment reduced overall lesion volume by about 37%. All these changes were statistically significant at p<0.05. Our findings suggest strongly that 8 OH DPAT is neuroprotective in the rat MCAo model of focal cerebral ischemia. |
| Key Words:
Middle cerebral artery occlusion; Serotonin; 8 OH DPAT; Brain ischemia; Lesion volume |
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