| Preliminary Result of Epilepsy Surgery in Patients with Neuronal Migration Disorder. |
| Sung Kyun Hwang, Chun Kee Chung, Chang Wan Oh, Sang Keon Lee, Je G Chi, Hyun Jib Kim, Dae Hee Han |
1Department of Neurosugery, College of Medicine, Seoul National University, Seoul, Korea.
2Department of Neurology, College of Medicine, Seoul National University, Seoul, Korea.
3Department of Patholgy, College of Medicine, Seoul National University, Seoul, Korea. |
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| ABSTRACT |
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Neuronal migration disorders (NMD's) are a rare group of developmental structural lesions characterized by disorganization of cortical architecture with aberrant columnar and laminar arrangement, often causing intractable seizures. During September 1994 to February 1995, we operated on six patients with NMD to treat intractable seizures, Male female ratio of these 6 patients was 2:4 and mean age at seizure onset was 14 years old(range 6-28 years), indicating early onset of epilepsy. Mean age at seizure surgery was 29 years old(range 23-41 years), and mean follow-up duration after operation was 4 months(range 3-6 months). In their past medical history, three patients had experienced febrile seizure at pediatric age, and one of them had a history of anoxic damage during delivery.
Following preoperative localization, the lesion was removed completely in five patients. In the other one patient part of the lesion was located the speech and motor area, leading to partial removal. On histologic examination, two of them showed cortical dysplasia and the other four revealed microdysgenesis. During follow-up for six months, five patients were free of seizure and in the other one patient, whose lesion was removed incompletely, the frequency of seizure decreased by 95%. |
| Key Words:
Neuronal migration disorder; Microdysgenesis; Cortical dysplasia; Intractable seizure |
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