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Journal of Korean Neurosurgical Society 1990;19(1): 21-30. |
| The Effect of Sciatic Nerve Transection on the Somatostatin and Substance P Cells in Dorsal Root Ganglia of Rats. |
| Sang Jin Kim, Ki Suk Koh, In Hyuk Chung |
1Department of Neurosurgery, National Medical Center, Seoul, Korea.
2Department of Anatomy, Yonsei University College of Medicine, Seoul, Korea. |
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| ABSTRACT |
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The authors investigated the morphometric analysis of substance P(SP)- and somatostatin(SOM)- containing nerve cells in dorsal root ganglia. For this purpose, immunohistochemical method was used to determine the number, size and the morphological characteristics of SP- and SOM-reactive cells in L5 dorsal root ganglia of rats. In addition, changes in type A, type B, SP- and SOM-containing nerve cells in ganglia after sciatic nerve transection were also determined. The results were as follows : 1) SP- and SPOM-reactive nerve cells belong to the population of type B cell, but N/C ratios of immunoreactive cells were higher than others ; 2) in normal group, SP- and SOM-reactive nerve cells were 12.5 and 3.2% of total nerve cells in ganglia, respectively ; 3) the case of coexistence of SP and SOM in one cell was not found ; 4) and there was a marked reduction in the number of SP- and SOM-reactive cells at 2 weeks after nerve injuries. And SP-reactive nerve cells were increased in number at 6 weeks after operation, but SOM-reactive cells were not. According to these results, SP- and SOM-reactive nerve cells belong to type B cells, but do not coexist in one cell. These nerve cells were decreased in number after nerve transection. SP-reactive nerve cells were recovered at 6 weeks after operation but recovery of SOM-reactive cell was not found. |
| Key Words:
Substance P cell; Somatostatin cell; Dorsal root ganglia; Sciatic nerve transection; Immunohistochemistry |
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