Spinal Hydatid Cyst Disease : Challenging Surgery - an Institutional Experience

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Abstract

INTRODUCTION

Hydatid cyst disease is caused by the parasite Echinococcus granulosus and occurs mostly in the liver and lung [2]. Humans are accidental intermediary hosts in the biological cycle of hydatid disease. They are infected directly from a dog bite or indirectly by drinking water or eating food contaminated with the eggs of the parasite [24]. The disease is rarely seen in the vertebral system, occurring at a rate of 0.2–1% [1,45]. Cysts are usually seen in highly vascularized parenchymal organs such as the brain, the liver, and the lung. Bone involvement is very rare. In our population, spinal hydatid cysts have become a challenge. The spongy part of the vertebral body seems to be one of the preferred sites. The pathological mechanisms remain unclear; hence, the surgical removal usually becomes problematic.

Obviously simple cyst puncture is not a solution. It is undetectable through which compartments in the vertebrae the scolex moves. Spinal hydatid cyst disease has high rates of morbidity, recurrence, and mortality. It is vital to excise the cyst together with its wall without rupturing it in the treatment. Rupture of the cyst may result in dissemination and chronic recurrence [30]. There are several published studies about spinal hydatid cysts [15,26,32,34]. To our knowledge, this is the largest Turkish study in the English literature on this subject. Here, in the context of the relevant literature, spinal hydatid cysts, multiple operations, chronic recurrences, and spinal hydatid cyst excision methods are discussed.

MATERIALS AND METHODS

Twelve spinal hydatid cyst cases were operated 29 times between 2005 and 2016. They were followed up clinically and radiologically for an average of 6.5 years (1–13). Their medical records and radiological investigations were reviewed retrospectively. Every patient is operated and cyst excision is performed. Patients are operated 1–6 times. In total, 29 operations are performed.

RESULTS

Of the 12 cases, six were males (mean age, 46.2 years) and six were females (mean age, 28 years). The overall mean age was 37.5 years. Eight patients lived in a rural environment, while four lived in an urban setting. The time from onset of symptoms to diagnosis was on average 3 months. In all patients, the initial clinical symptoms and signs were spinal. Motor or sensory deficits or altered reflexes were present in all patients. Seven of the patients had systemic hydatid cysts involving, for instance, the liver, lung or kidney. The characteristics of the patients are summarized in Table 1.

Table 1.

Properties of patients with spinal hydatid cyst disease

A preoperative analysis with CT scan and MRI is necessary. The number of segments involved and which columns of vertebrae are compromised must be determined. Spinal hydatid cyst disease is symptomatic when multiple segments and more than one vertebral column are corrupted. Extravertebral involvement can be identified with radiologic examination. The thorax and abdomen may be widely infected with the disease.

All patients are kept under routine follow up. As recurrences are common radiologic and clinical examination results are stored (Figs. 1-4). For all patients, posterior decompression with laminectomy, curettage of the lesion, aspiration of necrotic tissue, and drainage and washout of paravertebral cyst cavities is performed. Albendazole (400 mg p.o.) is administered twice daily for all patients. Medical treatment is started before the first surgery. Intraoperatively, the gauzes and cotton pads were soaked with hypertonic saline (3%). Intraoperatively, the wound was washed with hypertonic saline.

Fig. 1.

Patient 11. A : Sagittal T2A weighted MRI showing sacral hydatid cyst infection. B : Sagittal T2A weighted MRI showing sacral hydatid cyst infection and paravertebral involvement. C : Contast enhanced sagittal T1A weighted MR. D : contast enhanced axial T1A weighted MR. MRI : magnetic resonance imaging, MR : magnetic resonance.

Fig. 2.

Patient 7, thoracic hydatid cyst. Decompression and instrumentation surgery is performed. Recurrent disease can be seen in paravertebral area and subcutaneous tissue. A : T1A weighted sagittal MRI. B : Contrast enhanced T1A weighted sagittal MRI. C : Contrast enhanced T1A weighted sagittal MRI. D : T2A weighted axial MRI. R : right, L : left, MRI : magnetic resonance imaging.

Fig. 3.

Patient 1. Sagital (A) and axial computed tomography scan (B) of a sacral hydatid cyst patient, after 3rd operation.

Fig. 4.

Patient 4, X-Ray scan of a thoracic hydatid cyst patient. Spinal stabilization and laminectomy were performed. Antero-posterior (A) and lateral X-ray scan (B).

There were seven stabilization procedures with laminectomies. Over the follow-up period, eight patients underwent more than one operation for the disease (75%). Vertebral recurrences were universal. The average time for the first recurrence after surgery was 12 months. Five patients (42.5%) had two or more vertebrae involved with the disease. At the time of diagnosis, six out of 12 patients had extravertebral involvement. There were three wound-healing problems, and one patient had temporary paraparesis after thoracic hydatid cyst resection.

Continuous drainage of the cysts

During surgery, the surgeon can place a two-way drainage catheter inside the cyst. During postoperative treatment, the cyst should be washed with chlorhexidine solution (0.04% Chx-Glu) for 3 weeks.

In the figure, a patient lying on the bed is observed. The drainage catheter is placed inside the cyst cavity of the patient. During cyst excision surgery, the surgeon can place the catheter proximal end inside the cavity, the distal end of the catheter is placed outside the patient. This two-way drainage catheter can be used to wash out the cavity after surgery. First chlorhexidine solution (0.04% Chx-Glu) is injected. After 5 minutes of washing, the solution and the cyst content is emptied from the catheter exit. To the best of our knowledge, this is the first study emphasizing the use of a two way catheter to wash out the cyst cavity (Fig. 5).

Fig. 5.

Continuous drainage of the hydatid cyst.

DISCUSSION

Spinal hydatid cyst disease is an endemic disease generally seen in the Mediterranean and Middle East countries [1,2,16,35]. Spinal hydatid cyst disease is a rare and hard to treat disease. There are only a few articles in the literature worldwide (Table 2). Though mostly thoracic vertebral involvement is observed, cervical, lumbar, and sacral hydatid cysts can also occur [2,7,34-36]. Odontoid process involvement is extremely rare [6]. Among our cases, there were five thoracic vertebral, two cervical vertebral (one odontoid), and five lumbosacral vertebral cases. In six cases, there was extradural space and paravertebral area involvement, as summarized in Table 1. For diagnosis, physical examination and radiological studies such as CT and MRI scans are helpful. Serologically enzyme-linked immunosorbent assay, Western blot, indirect hemagglutination tests, and polymerase chain reactions are generally used for diagnosis [10]. Depending on the disease localization, the goal of the surgery is decompression of spinal cord and—if necessary—stabilization of the spinal column to compensate for loss of stability as a result of cyst excision [30]. We performed laminectomies and cyst excision in all cases, but six of them needed to be stabilized. Although it is known that albendazole alone cannot ensure recovery or prevent recurrence, when used as an ancillary application in inoperable patients or together with surgical treatment, it is useful in preventing or delaying recurrence or preventing intraoperative dissemination of the cyst [30]. Before the resection, to prevent further spread secondary to cyst rupture, a cysticidal agent (hypertonic 30% saline, cetrimide, or 70–95% ethanol) can be administered topically to destroy the cysts [32]. We administered hypertonic saline in all cases during the operation before and after cyst excision. The recurrence rate has ranged from 30% to 100% [5,11]. Recurrence was seen in nine cases (75%) in our series.

Table 2.

Spinal hydatid cyst disease cases in literature

Gezercan et al. [15] reported that even in patients who had a successful operation, recurrences are common. Long term follow up including serologic, clinical and radiologic tests should be performed. In our series, the results are parallel. In 12 reported cases, multiple operations are common. To add on, extradural space and paravertebral area involvement is seen in six patients.

Due to the multivesicular and more invasive nature of spinal hydatid cysts, their treatment method might be more difficult compared to that of intracerebral hydatid cysts. Subtotal excision and rupture of the cyst result in higher rates of recurrence [33]. Spinal hydatid cysts are classified into five categories for radiological purposes : intramedullar, intradural, extramedullar, extradural vertebral hydatid cysts, and paravertebral lesions [23]. We had eight extradural hydatid cyst cases with paravertebral involvement, one intradural case [23] and one case with only dural invasion. Neither surgical nor medical treatment is generally efficient in cases with bone involvement. Although the hydatid cyst is characterized as benign pathology, in consequence of its local growing pattern, it can be classified in the malign group because of its high potential for dissemination, which can result in high incidence of recurrences [15,21,22,43]. Spondylectomy can also be recommended for the treatment of cases accompanied by vertebral involvement; however, diseases frequently recur and become chronic [11].

CONCLUSION

Although spinal hydatid cyst disease is a benign pathology and is rarely seen, treatment should be aggressive and include total excision of the cyst without rupture, decompression of spinal cord, flushing of the area with scolicidal drugs, and ensuring spinal stabilization.

The surgeon dealing with spinal hydatid cyst infection should remember to administer albendazole treatment before surgery. Secondary wound infection is the most common morbidity after surgery. Postoperative antibiotics and wound care should be applied with utmost care. Recurrences are common for all spinal hydatid cyst patients. Routine radiologic and clinical follow up is necessary.

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