| Neuroprotective Effect of Anthocyanin on Experimental Traumatic Spinal Cord Injury. |
| Kyoung Tae Kim, Taek Kyun Nam, Yong Sook Park, Young Baeg Kim, Seung Won Park |
1Department of Neurosurgery, Kyungpook National University Hospital, Daegu, Korea.
2Department of Neurosurgery, College of Medicine, Chung-Ang University, Seoul, Korea. nspsw@cau.ac.kr |
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| ABSTRACT |
OBJECTIVE
We investigated the neuroprotective effect of anthocyanin, oxygen radical scavenger extracted from raspberries, after traumatic spinal cord injury (SCI) in rats.
METHODS
The animals were divided into two groups : the vehicle-treated group (control group, n=20) received an oral administration of normal saline via stomach intubation immediately after SCI, and the anthocyanin-treated group (AT group, n=20) received 400 mg/kg of cyanidin 3-O-beta-glucoside (C3G) in the same way. We compared the neurological functions, superoxide expressions and lesion volumes in two groups.
RESULTS
At 14 days after SCI, the AT group showed significant improvement of the BBB score by 16.7+/-3.4%, platform hang by 40.0+/-9.1% and hind foot bar grab by 30.8+/-8.4% (p<0.05 in all outcomes). The degree of superoxide expression, represented by the ratio of red fluorescence intensity, was significantly lower in the AT group (0.98+/-0.38) than the control group (1.34+/-0.24) (p<0.05). The lesion volume in lesion periphery was 32.1+/-2.4 microL in the control and 24.5+/-2.3 microL in the AT group, respectively (p<0.05), and the motor neuron cell number of the anterior horn in lesion periphery was 8.3+/-5.1 cells/HPF in the control and 13.4+/-6.3 cells/HPF in the AT group, respectively (p<0.05).
CONCLUSION
Anthocyanin seemed to reduce lesion volume and neuronal loss by its antioxidant effect and these resulted in improved functional recovery. |
| Key Words:
Spinal cord trauma; Anthocyanin; Antioxidants |
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