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Journal of Korean Neurosurgical Society > Volume 39(1); 2006 > Article
Journal of Korean Neurosurgical Society 2006;39(1): 58-60.
Gamma Knife Radiosurgery in Patients with a Hypothalamic Hamartoma Associated with Intractable Gelastic Epilepsy: Report of Three Cases.
Che Kyu Ko, Seok Ho Hong, Tae Sung Ko, Jung Kyo Lee
1Department of Neurosurgery, Asan Medical Center, College of Medicine, Ulsan University, Seoul, Korea. jklee@amc.seoul.kr
2Department of Pediatrics, Asan Medical Center, College of Medicine, Ulsan University, Seoul, Korea.
ABSTRACT
Hypothalamic hamartoma(HH) is an unusual nonneoplastic developmental lesion associated with gelastic epilepsy and precocious puberty, mostly found in children. Although open surgery has been attempted when antiepileptic medication failed to control seizures, its deep location and surrounding vital structures often rendered surgery unsuccessful. We describe the outcome of gamma knife radiosurgery in three children with a HH associated with gelastic epilepsy and reviewed the literature for a possible therapeutic mechanism.
Key Words: Hypothalamic hamartoma; Gelastic seizure; Gamma knife radiosurgery
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