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Journal of Korean Neurosurgical Society 2005;37(3): 193-196.
Treatment of Supratentorial Primitive Neuroectodermal Tumors (PNETs) in Children.
Jun Mo Hwang, Dong Won Kim, Sung Yeal Lee, Il Man Kim, Chang Young Lee, Man Bin Yim, Eun Ik Son
Department of Neurosurgery, Keimyung University School of Medicine, Daegu, Korea. dongwon@dsmc.or.kr
Strategies for managing supratentorial primitive neuroectodermal tumors(PNETs) in children include surgical resection, craniospinal irradiation and chemotherapy. This study is performed in order to compare the efficacy of various methods of treatment and to describe its optimal management. METHODS: We have reviewed all medical records and pathology slides of six children(four males and two females) with supratentorial PNET from November, 1987 to May, 2003. The extent of resection was confirmed by computed tomography and magnetic resonance studies. RESULTS: The patients were aged 1 to 13 years and treated postoperatively with/without adjuvant therapy. Tumor location included was four cortical, one gangliobasal, and one pineal region. The presenting symptoms and signs consisted of increased intracranial pressure and focal neurological deficits such as seizure and hemiparesis. The treatment consisted of surgical resection alone in one patient, postoperative radiotherapy in one patient, postoperative chemotherapy in one, and postoperative radiotherapy with chemotherapy in three. Five patients lived more than 12 months after diagnosis and one patient among them has been living more than 5 years after diagnosis. CONCLUSION: We can improve the survival and prognosis of supratentorial PNET patients by radical gross total resection of tumor followed by craniospinal irradiation and aggressive chemotherapy. First of all, gross total resection of tumor is the most important among many factors.
Key Words: Primitive neuroectodermal tumor; Surgical resection; Radiotherapy; Chemotherapy
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