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Journal of Korean Neurosurgical Society 2003;34(4): 369-371.
Familial Multiple Endocrine Neoplasia, Type I, in Identical Twins.
Wee Hyun Kwon, Moo Seong Kim, Yong Tae Jung, Jae Hong Sim
Department of Neurosurgery, Inje University, Busan Paik Hospital, Busan, Korea. 667196@hanmail.net
We report of case of one monozygotic twin sister with pituitary tumor and multiple endocrine neoplasia, type 1.The older sister, 31-year-old woman, had undergone Gamma Knife radiosurgery for prolactin producing pituitary microadenoma. Four years later, pancreatic insulinoma was detected, distal pancreatectomy and splenectomy were done. The younger sister, 31-year-old woman, had been operated for pancreatic insulinoma, 12 years ago. One year ago, hyperparathyroidism and pituitary macroadenoma were detected. Tumor removal was followed by Gamma Knife radiosurgery for residual tumor.
Key Words: Monozygotic twin; Pituitary tumor; Pancreatic insulinoma; Hyperparathyroidism; Familial multiple neoplasm type I
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