Cognition and Memory Impairment after Operation in Ruptured Cerebral Aneurysm Patients.

Kim, Byung Joo; Choi, Chang Hwa; Kim, Dae Jin

Original Article

Journal of Korean Neurosurgical Society 2001;30(7): 842-848.

Byung Joo Kim, Chang Hwa Choi, Dae Jin Kim

¹Department of Neurosurgery, Pusan National University College of Medicine, Pusan, Korea.
²Pusan Psychological Evaluation Center, Pusan, Korea.

ABSTRACT

OBJECTIVE
The mortality rate of subarachnoid hemorrhage(SAH) has been reduced recently due to refinement of microsurgical technique and improved perioperative management. Also, many survivors of SAH show excellent neurological recoveries. However, we found that a high proportion of the survivors do not fully regain their premorbid status in cognitive and memory function. Object of this study is to evaluate which factors might influence on cognitive and memory impairment in ruptured aneurysmal SAH patients.
METHODS
In this prospective study, a series of 66 patients with aneurysmal subarachnoid hemorrhage(SAH) from 1996 to 1998, most of whom had a "good" or "fair" neurological outcome, were assessed with various tests of cognition and memory function. All patients underwent clipping operation by pterional approach. Right side approach was performed in 16 case and left 21 cases. K-WAIS(Korean-Wechsler Adult Intelligence Scale) was used as method of cognition and memory function test. The time interval between SAH and assessment varied between 4 months and 8 months, averaging 6.2 months. Statistical analyses were carried out for each test score to see whether aneurysm site(A-com : non A-com), route of approach, age and sex, vasospasm, Hunt-Hess grade and Fisher CT group at admission, Glasgow Outcome Scale(GOS) at discharge affect cognitive and memory function.
RESULTS
Aneurysm site was not shown to be associated with performance on any test, and the initial grade (Hunt-Hess grade, Fisher CT group) of SAH and vasospasm had only minimal predictive values. The grade at discharge(GOS) was proved to be the best predictor of impairment of cognition and memory function within 1 year after operation.
CONCLUSION
The authors conclude that the diffuse effects of SAH are more important than focal neuropathology in relation to cognitive impairment in this group of patients.

Key Words: Subarachnoid hemorrhage; Memory; Cognitive impairment; Ruptured aneurysm