Comparison between Acetazolamide and Dipyridamole Activated SPECT for Cerebral Vascular Reserve Capacity Measurement.

Ban, Seong Bae; Moon, Jae Gon; Bae, Sang Kyun; Lee, Hyong Geun; Jeon, Byuong Chan; Kim, Han Kyu; Yum, Ha Yong; Lee, Hwa Dong

Original Article

Journal of Korean Neurosurgical Society 1999;28(2): 228-236.

Seong Bae Ban, Jae Gon Moon, Sang Kyun Bae, Hyong Geun Lee, Byuong Chan Jeon, Han Kyu Kim, Ha Yong Yum, Hwa Dong Lee

Department of Neurosurgery and Nuclear Medicine, Gospel Hospital, Kosin University Medical College, Pusan, Korea.

ABSTRACT

Object of this study was to make comparison between acetazolamide and dipyridamole activated SPECT for measurement of cerebral vascular reserve capacity. This study was also carried out to evaluate response in acetazolamide and dipyridamole activated SPECT in relation to clinical parameters, such as Glasgow Coma Scale, Hunt & Hess grade, Fisher grade and Glasgow Outcome Scale. It is concluded from study that. Acetazolamide and dipyridamole activated SPECT study proved to be valuable for cerebral vascular reserve capacity. Dipyridamole activated SPECT study was somewhat equivocal because of systemic vascular dilatation effect, but this problem could be resolved by Gamma Count Ratio. Although there were minimal transient side effect of dipyridamole such as dizziness, no complication.

Key Words: Dipyridamole SPECT; Acetazolamide SPECT; Cerebral vascular reserve capacity; Subarachnoid hemorrhage