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Journal of Korean Neurosurgical Society > Volume 26(11); 1997 > Article
Journal of Korean Neurosurgical Society 1997;26(11): 1513-1519.
Clinical and Pathophysiological Characteristics of Cerebral Gliomas without Enhancement on Magnetic Resonance Images.
Jung Il Lee, Do Hyun Nam, Jong Soo Kim, Seung Chyul Hong, Hyung Jin Shin, Kwan Park, Whan Eoh, Jong Hyun Kim
Department of Neurosurgery, Sung Kyun Kwan University College of Medicine, Samsung Medical Center, Seoul, Korea.
ABSTRACT
It is often assumed that a parenchymal brain lesion which shows no contrast enhancement on magnetic resonance imaging(MRI) is a"low-grade tumor". We investigated a series of 20 patients with nonenhancing cerebral gliomas ; all underwent stereotactic biopsy or open resection, and histological diagnoses were astrocytoma(n=7), anaplastic astrocytoma(n=7), oligodendroglioma(n=5), and ganglioglioma(n=1). Before surgery, 11 patients underwent [18F] fluorodeoxyglucose positron emission tomography(FDG-PET), and this showed hypermetabolic features in two of four patients with anaplastic astrocytomas and in one of seven with astrocytomas or oligodendrogliomas. Among 17 patients, the mean Ki-67 labeling index was 4.4+/-4.3(range : 0.1-16.7), and the standard error was 1.04. These results indicate that in cerebral gliomas, the enhancing pattern seen on MRI cannot predict the degree of malignancy, and we suggest that even if imaging is consistent with "low-grade glioma", histological verification and close follow-up of clinical course are both important.
Key Words: Magnetic resonance imaging; Nonenhancing tumor; Anaplasia
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