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Journal of Korean Neurosurgical Society 1996;25(4): 695-700. |
| Clinical Analysis of Lymphocyte Population Changes in Severe Head Injured Patients Using Flow Cytometry. |
| Ho Suk Jang, Young Seok Park, Young Bae Lee, Kyu Chun Lee, Chan Jung, Jin Ho Mok |
| Department of Neurosurgery, Dong-guk Universty, Kyoung Ju, Korea. |
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| ABSTRACT |
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Despite advancement in diagnosis and progress in the management of intracranial pressure, infection remains a common complication following severe head injury. This following study attempts to better define the cell mediated immunity that decreased immediately following severe head injury. Twenty-five patients admitted with severe head injury(mean Glasgow Coma Scale, 5.32) were studied at the emergency rooms. The control group consisted of 25 mildly head-injured patients requiring hospital observation.
Phenotyping of peripheral blood lymphocytes(PBL), determined by flow cytometry using monoclonal antibodies to lymphocytes subpopulation and HLA-DR receptors, was performed immediately following head injury. When severely head-injured patients were compared with controls, it was observed that the total T-cell counts(p<0.01) were markedly decreased, whereas the NK cell counts(p<0.01) were found to be increased. Infection rate of the study group was 44% and the majority of infections occur within the first 10 days after sever head injury. The results of this study suggests that severely head-injured patients had a decreased T-cell population and subpopulation in lines with higher infection rate. |
| Key Words:
Cell-mediated immunity; Head injury; T-cell; Infection |
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