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Journal of Korean Neurosurgical Society > Volume 20(12); 1991 > Article
Journal of Korean Neurosurgical Society 1991;20(12): 973-982.
Clinical Experience of Suprasellar Germ Cell Tumors.
Ho Yeol Zhang, Joong Uhn Choi, Sang Sup Chung, Kyu Chang Lee
Departments of Neurosurgery, Yonsei University, College of Medicine, Seoul, Korea.
ABSTRACT
The germ cell tumors are classified to germinoma, immature teratoma, mature teratoma, choriocarcinoma, yolk sac tumor and embryonal carcinoma. We analyzed 10 cases of suprasellar germ cell tumors which had been treated at Yonsei Uviversity Hospital from 1980 to 1990. Results of our study were summurized as follows : Common clinical symptoms are diabetes insipidus, visual dysfunction, panhypopituitarism, etc. Therapeutic plan can be based on serum and CSF AFP and HCG level. Pretreatment and posttreatment bormonal evaluation were performed and hrmonal replacement were required in all patients. Germinoma showed good outcome but immature teratoma showed bad outcome by multisystem involvement. More advanced new chemotherapeutic and immunotherapeutic agents must be studied for this tumor.
Key Words: Germ cell tumor; Germinoma; Teratoma; Tumor marker; Placental alkaline phophatase; Neoadjuvant chemotherapy
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