Creatine Phosphokinase Isoenzymes in Head Injury.

Kim, Bum Tae; Shin, Won Han; Kim, Sang Won; Choi, Soon Gwan; Byun, Bark Jang; Lee, In Soo

Original Article

Journal of Korean Neurosurgical Society 1989;18(3): 409-416.

Bum Tae Kim, Won Han Shin, Sang Won Kim, Soon Gwan Choi, Bark Jang Byun, In Soo Lee

Department of Neurosurgery, College of Medicine, Soonchunhyang University, Seoul, Korea.

ABSTRACT

We performed a electrophoresis to determine the serum level of isoenzyme of creatine phosphokinase in 30 patients with head injuries. The present study was undertaken to examine whether the measurement of serum level of brain type isoenzyme(CPK-BB) and heart type isoenzyme(CPKMB) were valuable in evaluating the clinical status of head injuries. All patients were diagnosed by Glasgow coma scale score, CT scan and then we performed a serial blood sampling during the first 7days. Brain type creatine phosphokinase(CPK-BB) was detected in the serum in 4 of 30 patientts(13.3%) and heart type creatine phosphokinase(CPK-MB) was detected in the serum in 8 of 30 patients(26.7%). These findings were seen within 48 hours after head injuries. The higher level were associated with severe brain damage; hemorrhagic contusion, subdural hemorrhage, subarachnoid hemorrhage and pneumocephalus.

Key Words: Head injuries; Electrophoresis; Creatine phosphokinase(CPK-BB, CPK-MB)