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Journal of Korean Neurosurgical Society 1985;14(2): 281-292. |
| Study on Receptor-Mediated Catecholamine Activation of Brain Cortical Na-K-ATPase. |
| Jin Mik Kim, Young Woo Lee |
| Department of Neurosurgery, School of Medicine, Pusan National University, Korea. |
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| ABSTRACT |
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In order to examine the properties of catecholic receptor-mediated activation of Na-K-ATPase reaction, author have studied. 1) the structure-activity relationships of various catechol analogues as stimulants of rat cortical Na-K-ATPase. 2) the stereospecificity of alpha and beta-adrenergic agonists on their activation of enzyme system and 3) the relationship of the receptive sites to the enzyme Na-K-ATPase and the effect of EDTA. The observed results were as follows: 1) Noradrenalin, dopamine and isoproterenol stimulated the Na-K-ATPase activity in rat cortical nomogenate. 2) The Na-K-ATPase activation elicited by catecholamines could not be antagonized by beta-receptor blocker, phentolamine and alpha-receptor blocker, propranolol decreased the increase in activity evoked by catecholamine, but it could not inhibit completely. 3) alpha-receptor blocker, phenoxybenzamine inhibited the noradrenalin activation on Na-K-ATPase, and decreased the effect of EDTA on the Na-K-ATPase activity. |
| Key Words:
Na-K-ATPase; Catechol analogues; Adrenergic agonists; Catecholic receptors; EDTA |
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