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Journal of Korean Neurosurgical Society 1999;28(7): 1008-1014. |
| Pleomorphic Xanthoastrocytomas: Report of Three Cases. |
| Choong Hyun Kim, Il Seung Choi, Koang Hum Bak, Jae Min Kim, Suck Jun Oh, Nam Kyu Kim |
| Department of Neurosurgery College of Medicine Hanyang University, Seoul, Korea. |
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| ABSTRACT |
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We report three cases of patient with pleomorphic xanthoastrocytoma(PXA). PXA is a clinicopathologically distinct variant of cerebral astrocytoma which is a low-grade leptomeningeal glioma affecting under the age of 30 years. This tumor has a favorable prognosis, but histological and neuroradiological findings suggest malignant brain tumor. Occasionally these may be confused with malignant gliomas. Clinical features from our three patients were manifestation of increased intracranial pressure and all cases were under the age of 30 years and females. Two patients had superficial location in the right frontal and left temporal respectively, but remaining one(case 2) which was associated with arteriovenous malformation in the left frontal region was in the right lateral ventricle. The intraoperative histological evidence by frozen biopsy suggested glioblastoma or anaplastic astrocytoma in all cases which confirmed to be PXA by postoperative histological examination. Two cases which had been resected subtotally were followed by cranial irradiation without therapeutic efficacy. Optimal management of PXA is primary surgical resection to reduce recurrence of tumor and to secure long-term survival. Therefore, differentiation of PXA from malignant brain tumors and intraoperative diagnosis of PXA is imperative to treat PXA effectively. |
| Key Words:
Pleomorphic xanthoastrocytoma; Glioma; Differentiation.Surgical resection |
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