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Journal of Korean Neurosurgical Society > Volume 26(11); 1997 > Article
Journal of Korean Neurosurgical Society 1997;26(11): 1502-1512.
Pathological Changes in the Rat Brain after Experimental Intraoperative Radiation.
Joo Han Kim, Yong Gu Chung, Han Kyeom Kim, Chul Yong Kim, Hoon Kap Lee, Ki Chan Lee
1Department of Neurosurgery, Korea University Hospital, College of Medicine, Korea University, Seoul, Korea.
2Department of Pathology, Korea University Hospital, College of Medicine, Korea University, Seoul, Korea.
3Department of Radiation Oncology, Korea University Hospital, College of Medicine, Korea University, Seoul, Korea.
ABSTRACT
The aim of this study was to investigate the response of normal brain tissue to intraoperative irradiation. Light microscopic studies were performed in order to evaluate cellular tissue change such as loss of molecular layer, difficulty in identifying six normal cortical layers, increased reactive gliosis, vascular endothlial cell proliferation and fibrosis in the cerebral cortex and immunohistochemical study used glial fibrillary acidic protein(GFAP). After craniectomy, the right hemisphere of 24 Sprague-Dawley rats was exposed to a single 10Gy dose of gamma rays for 4 minutes. The radiation effect was assessed 1 week(group A), 2 weeks(group B), 1 month(group C), 1.5 months(group D), and 2 months(group E) after irradiation ; degeneration of nerve cells was evident after 2 weeks. One month after irradiation(group C), the following findings were noted : loss of molecular layer, difficulty in identifying six normal cortical layers, increased reactive gliosis, vascular endothelial cell proliferation and fibrosis in the cerebral cortex. Two months after irradiation(group E), necrotic change was seen in the cortex, in addition to the findings described in group C. In conclusion, the following pathological changes were evident according to time, after intraoperative irradiation : loss of molecular layer, difficulty in identifying six normal cortical layers, increased reactive gliosis, vascular endothelial cell proliferation and fibrosis in the cerebral cortex. To clarify the late effects of intraoperative radiotherapy(IORT), and to compare these to the pathological changes seen after exopsure to other irradiation modalities, further study is needed.
Key Words: Intraoperative irradiation; GFAP; Reactive gliosis; Radiation injury
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