Medulloblastoma:An Analysis of Factors Influencing on Its Prognosis.

Cho, Byung Kyu; Wang, Kyu Chang; Kim, Il Han; Lee, Sang Il; Sim, Bo Sung; Choi, Kil Soo

Original Article

Journal of Korean Neurosurgical Society 1988;17(5): 929-942.

Byung Kyu Cho, Kyu Chang Wang, Il Han Kim, Sang Il Lee, Bo Sung Sim, Kil Soo Choi

¹Department of Neurosurgery, College of Medicine, Seoul National University, Seoul, Korea.
²Department of Therapeutic Radiology, College of Medicine, Seoul National University, Seoul, Korea.
³Department of Health Services & Hospital Management, College of Medicine, Seoul National University, Seoul, Korea.

ABSTRACT

Authors analyzed the results of treatment in 49 cases of medulloblastoma who had been operated upon at the Seoul National University Hospital from January 1972 to June 1987. There were 2 cases(4%) of postoperative mortality(death within postoperative one month) and 13 cases of late moratlity. The 3-year overall survival rate was 49.3% and 3-year disease-free survival rate was 48.5%. The risk period of recurrence was about 2 years after surgery. The 3-year survival rate was significantly better in "grow total resection" group, "radiation dose more than 50 Gy" group, and group II(23 cases operated after July 1982) (p<0.05). The rate of posterior fossa recurrence was lower in "gross total resection" group for the patients who received posterior fossa irradiation of more than 50 Gy.

Key Words: Medullobalstoma; Prognostic factors; Survival rate; Recurrence; Extent of surgical removal; Radiation dose